Wednesday, October 4, 2023

Diabetes drug Ozempic and weight-loss drug Wegovy appear to curb different cravings : NPR


Sufferers taking diabetes drug Ozempic or the weight-loss drug Wegovy are reporting a curious, really useful aspect impact. The medication appear to cut back folks’s cravings for alcohol, nicotine or even opioids.


Prescriptions for Ozempic have skyrocketed previously 12 months. The drug treats diabetes. It may purpose dramatic weight reduction. However many of us taking this medicine have spotted an enchanting aspect impact. This is Michaeleen Doucleff.

MICHAELEEN DOUCLEFF, BYLINE: All the way through the COVID pandemic, James Paul Grayson (ph) felt like his well being used to be crumbling. He received just about 40 kilos, were given recognized with hypertension, pre-diabetes and a center factor.

JAMES PAUL GRAYSON: Guy, this sucks (laughter). You understand, I were given some of these meds I by no means needed to take ahead of. So I used to be if truth be told lovely depressed about my well being.

DOUCLEFF: Grayson is 73 years previous. He is retired and lives in Clayton, Okla. He did not need extra center troubles, so he began taking Ozempic. The medicine is very pricey, nevertheless it labored instantly.

GRAYSON: Mainly, I began reducing weight nearly straight away.

DOUCLEFF: Then he spotted one thing else. He went out to dinner, ordered a lager, and…

GRAYSON: I may just slightly end it.

DOUCLEFF: It did not really feel or style excellent.

GRAYSON: Every so often, you drink a lager, and it is, like, oh, my God, it tastes so excellent. Guzzle, guzzle, guzzle, guzzle. Smartly, I did not really feel like guzzling. I simply slightly felt like sipping it.

DOUCLEFF: This wasn’t like Grayson. Whilst he by no means idea he had an issue with alcohol, he did like ingesting beer and wine.

GRAYSON: You understand, I may just devour a complete bottle of wine in a night with out making an attempt actual exhausting – together with a bag of sweets (laughter).

DOUCLEFF: However the medicine zapped his motivation for each the chocolate and the wine.

GRAYSON: I would have wine within the fridge or no matter. I am, like, perhaps I will have to have some wine. After which I simply roughly put out of your mind about it. I believe I simply watch extra TV.

DOUCLEFF: He would possibly now not have discovered it, however Grayson used to be most likely experiencing a transformation within the unlock of dopamine within his mind. Dopamine is a chemical that makes us need or crave issues. Christian Hendershot is a psychologist on the College of North Carolina. He says that many of us taking Ozempic or some other model referred to as Wegovy have had an identical aversions to alcohol.

CHRISTIAN HENDERSHOT: There may be in point of fact been a lot of medical and anecdotal experiences coming in – it is in point of fact from around the nation – simply suggesting that folks’s ingesting behaviors are converting and in some circumstances, lovely considerably.

DOUCLEFF: He is main one among six medical trials having a look at whether or not those weight reduction medicines can lend a hand deal with alcohol use dysfunction.

HENDERSHOT: There appears to be nearly a satiety impact the place folks both come to a decision to not start up ingesting or, if they have got began, that they do not really feel the wish to proceed.

DOUCLEFF: And here is what’s much more unexpected – it isn’t simply with alcohol.

HENDERSHOT: The similar issues were reported for cigarette smoking.

DOUCLEFF: In different phrases, Ozempic might curb many various kinds of cravings, together with nicotine and opioids. Even though there were only some research in folks, scientists were learning this impact in rats for greater than a decade.

ELISABET JERLHAG: So somewhat a very long time now.

DOUCLEFF: That is Elisabet Jerlhag. She’s a pharmacologist on the College of Gothenburg in Sweden. She and her colleagues have proven that Ozempic reduces binge ingesting in rats and stops relapses in animals hooked on alcohol.

JERLHAG: We see a discount on alcohol intake through over 50%, which is somewhat dramatic.

DOUCLEFF: So how does a weight reduction medicine scale back alcohol cravings? Alexandra DiFeliceantonio is a neuroscientist at Virginia Tech. She says the mechanisms within the mind that purpose folks to overeat overlap with those who purpose habit. Particularly, she says, meals with a lot of sugar and fats build up dopamine in a particular a part of the mind within the heart that reasons motivation.

ALEXANDRA DIFELICEANTONIO: That build up in dopamine is if truth be told in point of fact very similar to person who we see after nicotine intake or after alcohol intake. All addictive medication build up dopamine. That in point of fact is, like, the hallmark of an addictive drug.

DOUCLEFF: This is how that dopamine works. Consider for a 2d taking a chunk of a heat, gooey chocolate chip cookie. That chunk triggers a spike of dopamine to your mind, and that spike tells you…

DIFELICEANTONIO: Oh, hello, pass do that once more.

DOUCLEFF: Take some other chunk. The similar factor occurs you probably have a gulp of beer. Dopamine spikes and tells you, take some other gulp. Have extra. However research in folks display that Ozempic-like medication scale back the dopamine launched in each instances – makes the spikes a lot smaller. So that you decelerate and finally end up sipping the beer and taking just one chunk of a cookie.

This revel in has change into so not unusual that some medical doctors at the moment are prescribing Ozempic to regard alcohol use dysfunction, although it isn’t authorized for this. Dr. Lorenzo Leggio is the medical director of the Nationwide Institute of Drug Abuse. He says that is nice if an individual additionally has diabetes or weight problems.

LORENZO LEGGIO: Completely. Discuss together with your physician. And if that may lend a hand to additionally curb your ingesting, your yearning, there might be an added price.

DOUCLEFF: The drugmaker, Novo Nordisk, says it isn’t undertaking any medical trials to check those medicines for addiction-related sickness. However one small trial suggests Ozempic would possibly now not lend a hand with alcohol use in the event you shouldn’t have weight problems.

LEGGIO: No medicines are going to paintings for everyone.

DOUCLEFF: Even supposing it is nonetheless early, some persons are the usage of those medicines with the hopes of curtailing alcohol intake. Meg Johnston (ph) is one among them. She’s an actual property agent in Washington, D.C., and he or she not too long ago began taking Ozempic each to reduce weight and to cut back her ingesting.

MEG JOHNSTON: I in point of fact did numerous analysis ahead of entering this, so I used to be absolutely anticipating that.

DOUCLEFF: She says the drugs has led to numerous tough unintended effects, which can be not unusual.

JOHNSON: The ones first couple weeks had been very a lot desirous about now not vomiting, ensuring I proceed to have bowel actions.

DOUCLEFF: However nonetheless, the drugs straight away lowered her ingesting. She says many days, she does not even take into consideration having a tumbler of wine.

JOHNSON: It does not sound as appetizing. Moreover, you’re feeling it after so much tougher, too. The hangover or normal uneasiness feeling comes so much faster.

DOUCLEFF: Like you will have misplaced the style for it, nearly.

JOHNSON: Sure, really.

DOUCLEFF: Now, she says, the large query is what’s going to occur when she stops taking Ozempic. Many of us regain the burden they have got misplaced, however it is nonetheless unknown if they’re going to additionally regain the will to drink. For NPR Information, I am Michaeleen Doucleff.


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